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. 2019 Aug 8;14:6339–6356. doi: 10.2147/IJN.S209722

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© 2019 Pangeni et al.

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(A) Relative apparent permeability of PMX/DCK-OP across a Caco-2 cell monolayer after incubation with various transport inhibitors and (B) with or without EGTA in the presence or absence of all inhibitors except cyclosporine A.

Notes: Each value represents the mean ± standard deviation (n=6). **P<0.01, ***P<0.001 compared to the P_app of the untreated control group. ^###P<0.001 compared to the apparent permeability of PMX/DCK-OP after treatment with all inhibitors except cyclosporine A in the absence of EGTA. ^$$$P<0.001 compared to the P_app of PMX/DCK-OP after treatment with EGTA in the presence of all inhibitors except cyclosporine A.

Abbreviations: PMX, pemetrexed; DCK, N^α-deoxycholyl-L-lysyl-methylester; PMX/DCK, ion-pairing complex between PMX and DCK; PMX/DCK-OP, oral powder formulation of PMX/DCK; Act D, actinomycin D; MβCD, methyl-β-cyclodextrin; ASBT; EGTA, ethylene glycol-bis-(β-aminoethyl ether)-N,N,N′,N′-tetraacetic acid; P_app, apparent permeability of PMX/DCK-OP across a Caco-2 cell monolayer.