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. 2019 Aug 8;14:6339–6356. doi: 10.2147/IJN.S209722

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© 2019 Pangeni et al.

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Venous plasma concentration-time profiles of PMX after (A) single intravenous administration of PMX (5 mg/kg) and (B) oral administration of PMX (25 mg/kg), PMX/DCK (equivalent to 25 mg/kg of PMX), or PMX/DCK-OP (equivalent to 25 mg/kg of PMX) in aqueous solution to rats.

Notes: Each value represents the mean ± standard deviation (n=4 for each group).

Abbreviations: PMX, pemetrexed; DCK, N^α-deoxycholyl-L-lysyl-methylester; PMX/DCK, ion-pairing complex between PMX and DCK; PMX/DCK-OP, oral powder formulation of PMX/DCK.