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. 2019 Aug 8;14:6339–6356. doi: 10.2147/IJN.S209722

Figure 5.

Figure 5

Efficacy of in vivo tumor growth inhibitory effects in B16F10 tumor-bearing mice after biweekly intravenous administration of 20 mg/kg PMX (PMX-IV), intraperitoneal administration of 10 mg/kg anti-PD1 (Anti-PD1) once every 3 days, once-daily oral administration of PMX/DCK-OP as 20 mg/kg PMX (PMX/DCK-OP), and combined treatment with once-daily oral administration of PMX/DCK-OP as 20 mg/kg PMX and intraperitoneal administration of 10 mg/kg anti-PD1 (PMX/DCK-OP+Anti-PD1) once every 3 days for 14 days. (A) Tumor volume in mice (**P<0.01, ***P<0.001). (B) Variation of body weight in mice during treatment. (C) Tumor weight in B16F10 tumor-bearing mice (**P<0.01, ***P<0.001 compared to the control group). (D) Photographs of tumors isolated from each group on day 15. Scale bar represents 10 mm.

Notes: Statistics: one-way ANOVA followed by Tukey’s multiple-comparison test. Each value represents the mean ± standard deviation (n=10 for each group).

Abbreviations: PMX, pemetrexed; DCK, Nα-deoxycholyl-L-lysyl-methylester; PMX/DCK, ion-pairing complex between PMX and DCK; PMX/DCK-OP, oral powder formulation of PMX/DCK.