Table 2.
Effective and apparent permeability of PMX, PMX/DCK, and PMX/DCK-OP
| Test material | Effective permeability (Pe, ×10−6, cm/s)a | Apparent permeability (Papp, ×10−6, cm/s)b |
|---|---|---|
| PMX | 0.290±0.080 | 1.78±0.118 |
| PMX/DCK | 10.5±1.97*** | 5.97±1.38* |
| PMX-OP | 1.44±0.180 | 3.45±0.531 |
| PMX/DCK-OP | 40.6±1.48***,###,$$$ | 14.7±3.98***,###,$$$ |
Notes: Statistics: one-way ANOVA followed by Tukey’s multiple-comparison test. aEffective permeability (Pe) of PMX, PMX/DCK, PMX-OP, and PMX/DCK-OP through an artificial intestinal membrane. bApparent permeability (Papp) of PMX, PMX/DCK, PMX-OP, and PMX/DCK-OP across a Caco-2 cell monolayer. Each value represents the mean ± standard deviation (n=6). *P<0.05, ***P<0.001 compared to PMX; ###P<0.001 compared to PMX/DCK; $$$P<0.001 compared to PMX-OP.
Abbreviations: PMX, pemetrexed; DCK, Nα-deoxycholyl-L-lysyl-methylester; PMX/DCK, ion-pairing complex between PMX and DCK; PMX-OP, oral powder formulation of PMX; PMX/DCK-OP, oral powder formulation of PMX/DCK.