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. 2019 Aug 12;9:11634. doi: 10.1038/s41598-019-48051-1

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Detection of CD68+ TAMs, and c-Myb in BC patient samples according to the ER/PgR/HER2 status. (a) c-Myb and CD68 proteins in BC tissues were detected by IHC. Invasive ductal BCs, left - luminal A subtype (>50% of c-Myb+ tumor cells, low number of CD68+ cells), right - triple negative case (<5% of c-Myb+ tumor cells, high number of CD68+ cells). (b) Absolute amount of CD68+ cells in 40 high power fields X1350 in different subtypes. (c) Correlation between percentage of c-Myb+ tumor cells and number of CD68+ cells as determined by IHC in a cohort 86 BC patients. Pearson correlation coefficient (r), logrank p value (p) and number of patients (n) are indicated.