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. 2019 Aug 12;9:11592. doi: 10.1038/s41598-019-48078-4

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Iron Accumulation Assessment using MRI. (A) Representative Pearl Stained slides showing increased iron accumulation in the spleen and liver of the uninjected animals compared to IUGT 32 Weeks, (Scale Bar 50 μm). (B) T2 relaxation times for the IUGT 32 Weeks group, were not different in the Heart (p = 0.26–0.98, one-way ANOVA, Bonferroni’s Multiple comparisons test) compared to uninjected thalassemia control. (C) T2 relaxation times were different in Liver of the IUGT 32 Weeks group (13.5 ± 1.65 vs 8.068, n = 6, p = 0.0017) compared to uninjected thalassemia control and similar to Humanised non-thalassemia control (p = 0.52, one-way ANOVA, Bonferroni’s Multiple comparisons test). (D) T2 relaxation times in IUGT 32 Weeks group were not significantly different in Spleen (p = 0.41, one-way ANOVA, Bonferroni’s Multiple comparisons test) when compared to uninjected thalassemia control. (E) T2* relaxation times were different in the Heart of the IUGT 32 Weeks group (19 ± 1.40 vs 8.07 ± 0.77, n = 6, p = 0.0019) compared to uninjected thalassemia control and similar to Humanised non-thalassemia control (p = 0.32, one-way ANOVA, Bonferroni’s Multiple comparisons test). (F) T2* Relaxation Times in the Liver of IUGT 32 Weeks animals were significantly shortened 5.36 ± 0.91, n = 6 compared to Humanised Non-Thalassemia Control 9.34 ± 0.83, n = 6, p = 0.008 but not significantly different from the uninjected Thalassemia Control group, 4.76 ± 0.73, n = 6, p = 0.61, one-way ANOVA, Bonferroni’s Multiple comparisons test. (G) T2* in the spleen of IUGT 32 Weeks were significantly shortened 0.81 ± 0.27, n = 6 compared to Humanised Non-Thalassemia Control 1.72 ± 0.09, n = 6, p = 0.02 but not significantly different from the uninjected Thalassemia Control group, 0.60 ± 0.21, n = 6, p = 0.48, one-way ANOVA, Bonferroni’s Multiple comparisons test.