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. 2019 Aug 12;9:11666. doi: 10.1038/s41598-019-48053-z

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Endothelial RhoA deficiency is not detrimental for embryonic development. (A) Schematic diagram of RhoA transgenic mice carrying the Tie2-Cre endothelial-specific promoter and the RhoA floxed construct to generate RhoA-deficient endothelial cells upon endogenous promoter activation in mouse embryo. (B) Mating strategy to generate the RhoA^f/f Tie2-Cre+ line, with ratio of expected and obtained genotypes. (C) Number of mouse pups with the corresponding genotypes. (D) Western blot analysis of RhoA expression in isolated mouse lung endothelial cells from endothelial RhoA-deficient mice and the corresponding littermate controls (n = 3). Full-length blots are presented in Supplementary Fig. 6. ***P < 0.001.