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Effect of endothelial RhoA deficiency on VEGF- and S1P-induced cell migration and sprout formation in vitro. Quantification of mouse VEGF- (50 ng/ml) and S1P-induced (250 nM) cell migration (n = 3) (A) and sprout formation (n = 3) (B,C) of mouse lung ECs from RhoAΔEC mice and littermate controls. (B) Representative images and (C) quantification of number of nodes, number of junctions and total junction length. *P < 0.05; **P < 0.01; ***P < 0.001.
