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. 2019 Aug 12;9:11649. doi: 10.1038/s41598-019-48204-2

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Effects of vorinostat on globin gene expression in human erythroid cells. Erythroid cells differentiated from human adult CD34⁺ cells were incubated with a dose range (0–500 nM) of vorinostat for 72 hours on day 7 of the differentiation and globin gene expression was analysed using qRTPCR. (A) α, β and γ-globin expression relative to RPL13A expression. (B) α/β-globin mRNA ratio. (C) α/(β + γ) globin mRNA ratio. (D) γ/β-globin mRNA ratio. Mean expression levels from 3 independent biological repeats are shown; error bars represent SD; *p < 0.05, **p < 0.01 and ***p < 0.001 relative to the 0 nM concentration.