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. 2019 Aug 12;9:11649. doi: 10.1038/s41598-019-48204-2

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Effect of vorinostat on the erythroid transcriptome. Erythroid cells differentiated from human adult CD34⁺ cells were incubated with vorinostat (500 nM) for 72 hours on day 7 and the microarray analysis was performed on day 10 of erythroid differentiation (n = 3). Low expressing genes were filtered out when comparing the expression levels. (A) Scatter plot of Log₂ mRNA abundance of all the transcripts in vorinostat or DMSO treated cells demonstrating very high (r = 0.99) and statistically significant (p < 0.0001) correlations. (B) Validation of microarray data by nanostring; mRNA fold changes of several genes in the same RNA samples used in microarray were independently quantified by nanostring; high correlation (r = 0.87) between data sets validates microarray.