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. 2019 Aug 12;9:11695. doi: 10.1038/s41598-019-48081-9

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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VitD restores EVE sensitivity in HCC EveR cells. (A) VitD treatment induces inhibition of colony formation (surviving fraction) in PLC/PRF/5 EveR cells after 24 hrs of pre-treatment and 21 days of co-treatment with EVE. The data presented are mean ± SEM of three independent experiments. ****p < 0.0001 EVE 10⁻⁸ M + VitD 10⁻⁷ M vs control, ****p < 0.0001 EVE 10⁻⁸ M + VitD 10⁻⁷ M vs VitD 10⁻⁷ M, ****p < 0.0001 EVE 10⁻⁸ M + VitD 10⁻⁷ M vs EVE 10⁻⁸ M. VitD restores EMT markers expression in HCC EveR cells. E-cadherin (B,C) and cytokeratin 18 (C) expression in PLC/PRF/5 EveR and JHH-6 EveR cells after 6 days of VitD treatment. In IF staining: blu represents DAPI staining of the nuclei; red represents TRITC staining of vimentin protein; green represents FITC staining of E-cadherin protein. All the pictures were captured at 40X magnification.