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. 2019 Aug 12;9:11695. doi: 10.1038/s41598-019-48081-9

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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(A) Gene structures of MTDH, YAP-1 and c-MYC showing the predicted target site of miR-375. Oncogenes regulation by miR-375. (B) Luciferase report assay in PLC/PRF/5 EveR and JHH-6 EveR cells showing that c-MYC is target of miR-375. The data presented are mean ± SEM of three independent experiments. ****p < 0.0001; ***p < 0.001. (C) VitD reduces MTDH, YAP-1 and c-MYC protein expression after 6 days of treatment in PLC/PRF/5 EveR and JHH-6 EveR cells. (D) Inhibition of miR-375 induced MTDH, YAP-1 and c-MYC protein up-regulation in both EveR cells. The same proteins, instead, were down-regulated in presence of VitD and vehicles. Conversely, MTDH, YAP-1 and c-MYC proteins were up-regulated in presence of both miR-375 inhibitor and VitD. These effects are particularly visible in PLC/PRF/5 EveR cells.