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. 2019 Aug 12;9:11632. doi: 10.1038/s41598-019-48064-w

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Introduction of SH3GL2 inhibited tumorigenic progression of BCa cells in vitro and in vivo and decreased SPANXB1 expression. SH3GL2 overexpression in SUM-159 cells (A) reduced invasion (B), filopodium like protrusion formation (C) and pulmonary metastasis (arrows) in vivo (D). (E) Microarray analysis of SH3GL2-overexpressing SUM-159 cells exhibited 12.1 fold decrease of SPANXB1 mRNA expression (arrow). (F) SH3GL2 overexpression reduced SPANXB1 expression in TNBC cells. VC: Empty vector control; SH3GL2: SH3GL2 transduced (A–D). VC: Empty vector control; GL2: SH3GL2 transduced (F). Magnification × 200 (B,C). In Western blotting, all experimental and control antibodies were run in parallel for the same immunoblot. The Image J software (https://imagej.nih.gov/ij/) was used for Western blot quantification.