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. 2019 Aug 12;9:11606. doi: 10.1038/s41598-019-48115-2

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Localization of CYLD in muscle fibres of sIBM patients. (a–f) Representative immunohistochemical staining for CYLD using biopsy specimens of skeletal muscles from patients with sIBM (a–c), dermatomyositis (d), progressive muscular atrophy (e), and healthy control (f). Nuclei were stained with haematoxylin. Scale bars = 100 μm. (g–l) Confocal microscopic analysis of localisation of CD4 (g) or CD8 (j) and CYLD (h,k) in muscles of patients with sIBM. Merged images are presented in (i) and (l). Arrows indicate colocalization of CD4 or CD8 with CYLD. Scale bars = 50 μm.