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. 2019 Aug 12;9:11606. doi: 10.1038/s41598-019-48115-2

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Colocalization of CYLD with phosphorylated TDP-43 in muscle fibres of sIBM patients and TDP-43 TG mice. (a–t) Confocal microscopic analysis of localization of phosphorylated TDP-43 (a,e,i,m,q) and CYLD (b,f,j,n,r) in muscles of patients with sIBM (a–d), dermatomyositis (e–h), healthy control (i–l), and TDP-43 TG (m–p) or NTG mice (q–t). Nuclei were stained with 4′,6-diamidino-2-phenylindole (DAPI). Merged images are presented in (d,h,l,p,t). Arrows indicate colocalization of phosphorylated TDP-43 with CYLD. Scale bars = 50 μm. (U) Percentages of myofibres with colocalization of phosphorylated TDP-43 and CYLD in each group. n = 3–15 per group. ***P < 0.001; ****P < 0.0001.