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. 2019 Aug 12;9:11601. doi: 10.1038/s41598-019-48014-6

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Expression of L381P renin variant induces alteration in the pronephros of zebrafish embryos. The pronephros of 5 dpf zebrafish embryos is labelled by reporter transgene EGFP (line ia20Tg¹⁷). (a–c) Embryos injected with wild type (WT), L381P and L16del renin mRNAs show three different phenotypes: normal convoluted pronephric tubules; tubules with reduced convolutions (mild phenotype); absence of tubular convolution (severe phenotype). (d) Histograms showing the percentage of embryos with normal pronephros, or mild or severe pronephric alterations. Samples injected with renin mutants L381P (n = 112) and L16del (n = 122) show significantly increased frequency of altered pronephric tubules relative to wild type (n = 183) (chi-square analysis).