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. 2019 Aug 6;6:107. doi: 10.3389/fcvm.2019.00107

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Copyright © 2019 Beffagna.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Visualization of heart regeneration in adult zebrafish. After injury the heart activated factors, such as epicardial IGF, able to activate the Ras/MAPK pathway. These activated epicardial cells drive cardiomyocyte regeneration after injury and are essential for cardiomyocyte proliferation in heart regeneration.