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. 2019 Aug 6;13:360. doi: 10.3389/fncel.2019.00360

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Copyright © 2019 Liu, Zhang, Liu, Tang, Shu, Bao, Zhang, Gu, Xu and Cao.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Silencing TMEM16A exerts its BBB protective effect by decreasing ICAM-1 expression via the NF-κB signaling pathway. (A,B) ICAM-1 protein expression following OGD/R treatments with TMEM16A knockdown, with or without PDTC treatment. (C) Quantification of transendothelial permeability detected by dextran leakage and (D) a TEER assay. Values are the mean ± SEM. Two asterisks indicate P < 0.01 vs. control groups. One number sign indicates P < 0.05 and two number signs indicate P < 0.01 vs. OGD/R alone groups.