TABLE 2.
α7 nAChR subunit mRNA expression in ganglia of the developing peripheral nervous system (PNS).
|
Age |
||||
| Ganglion | E13 | E15 | E17 | P0 |
| Sensory | ||||
| Trigeminal (V) | ++ | +++/++++ | +++/++++ | +++/++++ |
| Dorsal root | + | +++/++++ | +++/++++ | +++/++++ |
| Autonomic ganglia | ||||
| Sympathetic | ||||
| Superior cervical | +++ | ++++ | ++++ | ++++ |
| Stellate | +++ | ++++ | ++++ | ++++ |
| Celiac | +++ | ++++ | ++++ | ++++ |
| Mesenteric | +++ | ++++ | ++++ | ++++ |
| Parasympathetic | ||||
| Submandibular (VII) | +++ | +++ | +++ | +++ |
| Otic (IX) | +++ | ++++ | ++++ | ++++ |
| Vagal (X) | +/++ | ++/++++ | ++/++++ | ++/++++ |
| Intracardiac | +++ | +++ | +++ | +++ |
| Intramural | +++ | ++++ | ++++ | +++ |
| Enteric | + | +++ | +++ | ++/+++ |
Intensity is based on silver grain counts: + (>10 grains/25 μm2), ++ (>20 grains/25 μm2), +++ (>50 grains/25 μm2), and ++++ (>90 grains/25 μm2). A double quantitative score indicates signified lower levels of mRNA surrounding spots of more intense signal.