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. 2019 Aug 12;9:11670. doi: 10.1038/s41598-019-48196-z

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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In vitro characterization of two PFKFB3 inhibitors. (a) Incubation of A549 cells with AZ67 (1 h) dose-dependently decreases F2,6BP concentration. (b) Incubation of A549 cells with PFK158 (1 h) dose-dependently decreases F2,6BP concentration. (c) Incubation of human recombinant PFKFB3 with AZ67 dose-dependently inhibits PFKFB3 kinase activity. (d) Incubation of human recombinant PFKFB3 with PFK158 does not inhibit PFKFB3 kinase activity. See also Supplementary Data 1.