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. 2019 Aug 6;11:207. doi: 10.3389/fnagi.2019.00207

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Copyright © 2019 Maulik, Mitra, Basmayor, Lu, Taylor and Bult-Ito.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Silencing of fat metabolism genes resulted in differential fat levels in models of Caenorhabditis elegans (C. elegans). (A) Confocal images and graphical representation of the Nile red staining as a measure of total fat content in (B) TG2435 (C) OW13 (D) JVR208 (E) JVR203 day 3 worms after gene silencing of fat metabolism genes. The worms (n = 10–12 per group) were grown on different RNA interference (RNAi) treatments: L4440, fat-5, fat-7, nhr-49 and tub-1 genes. Treatment with fat-5 and fat-7 genes (±4 μm rotenone) showed significantly low-fat content compared to the empty vector, L4440 (^#p < 0.05, ***p < 0.001 and *p < 0.05). Treatment with tub-1 (±4 μm rotenone) shows significantly high fat content than the L4440 control (^#p < 0.05, ***p < 0.001 and *p < 0.05). Each experiment was repeated two to three times. Scale bar 200 μm.