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. 2019 Aug 6;11:207. doi: 10.3389/fnagi.2019.00207

Figure 2.

Figure 2

Silencing of fat-5 and fat-7 genes reduced human wild-type α-synuclein expression in OW13 model of C. elegans. Graphical representation of (A) fluorescence intensity of the OW13 (n = 20–30 animals per group). (B) Representative confocal images of the α-synuclein/YFP expression in the head region of day 7 OW13 adults, magnification 40× and scale bar 50 μm. (C) Heat tolerance and (D) osmotic tolerance (E) viable progeny (F) body bend (G) pharyngeal pump rate (H) lifespan of OW13 animals fed on different genetic RNAi treatments (L4440, fat-5, fat-7, nhr-49 and tub-1). Empty vector L4440 was considered as control. The data represent the mean ± SEM with significant differences between the control and treatments at *p < 0.05, **p < 0.001 and ***p < 0.0001. Each experiment was repeated two to three times.