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. 2019 Aug 6;9:739. doi: 10.3389/fonc.2019.00739

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Copyright © 2019 Chen, Lu, Tan, Li, Wang and Wei.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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LncRNA-based therapeutic methods in cancer. (A) Transcriptional degradation: Short interfering RNAs (siRNAs), which are double-stranded RNAs, can degrade target RNAs through RISC (RNA-induced silencing complex). Antisense oligonucleotides (ASOs), which are single-stranded oligonucleotide sequence, offer specific complementarity, and Rnase H-mediated degradation of target lncRNA. (B) Inhibition interactions: Small molecules can inhibit the interaction between lncRNAs and protein. (C) Functional inhibition: Aptamers (short RNA or DNA oligonucleotides with 3-dimensional structure) can bind to their target lncRNAs at specific structural regions.