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. 2019 Aug 6;9:739. doi: 10.3389/fonc.2019.00739

Table 1.

LncRNAs involved in the crosstalk between stromal cells and tumor cells.

LncRNA Cancer type Stromal cells Mechanisms of action Reference
LncRNA-CAF Oral squamous cell carcinoma CAFs Lnc-CAF up-regulates IL-33 expression to reprogram CAFs, promoting tumor development. (36)
LINC00092 Ovarian cancer CAFs CAFs-secreted CXCL14 induces LINC00092 upregulation which promotes ovarian cancer metastasis by enhancing PFKFB-2 translation. (37)
LncRNA-ZEB2NAT bladder cancer CAFs TGFβ1 secreted by CAFs induces epithelial-mesenchymal transition and invasion of bladder cancer cells via lncRNA-ZEB2NAT. (34)
HOTAIR Breast cancer CAFs TGFβ1 secreted by CAFs induces epithelial-mesenchymal transition and metastasis of breast cancer through HOTAIR. (35)
LncRNA H19 Glioma endothelial cells Knockdown of H19 suppresses proliferation and migration of glioma-associated endothelial cells through upregulating miR-29a. (39)
LncRNA-APC1 Colorectal carcinoma endothelial cells LncRNA-APC1 suppresses the MAPK pathway overactivation in endothelial cells and further inhibits tumor angiogenesis by increasing exosome production in colorectal carcinoma cells. (40)
LncRNA CCAT1 Prostate cancer TAMs LncRNA CCAT1 knockdown enhances macrophages polarization to M2 and promotes prostate cancer cell migration and invasion through upregulating the expression of miR-148a. (45)
LncRNA NIFK-AS1 Endometrial cancer TAMs LncRNA NIFK-AS1 suppresses the M2 macrophages polarization by inhibiting miR-146a, thus reducing the endometrial cancer cell proliferation, migration and invasion. (46)
LncRNA-MM2P TAMs LncRNA-MM2P promotes M2 polarization of macrophages via reducing phosphorylation on STAT6, then affecting macrophage- mediated tumorigenesis and tumor growth. (47)
LncRNA LNMAT1 Bladder cancer TAMs LncRNA LNMAT1-induced CCL2 recruits TAMs, leading to lymphatic metastasis of bladder cancer. (51)
Lnc-BM Breast cancer TAMs Lnc-BM induces STAT3-dependent expression of CCL2 to attract macrophages, thus enhancing breast cancer brain metastasis. (52)
Lnc-chop MDSCs Lnc-chop upregulates the production of ROS and NO to enhance immunosuppression and promots tumor growth. (56)
Lnc-C/EBPβ MDSCs Lnc-C/EBPβ suppresses the immunosuppressive capacity of MDSCs by suppressing the expression of NO and ROS. (57)
LncRNA Pvt1 MDSCs LncRNA Pvt1 knockdown suppresses G-MDSC-mediated immunosuppression in vitro by decreasing the level of ROS and ARG1, and delays tumor progression in tumor-bearing mice. (61)
Lnc-Tim3 Hepatocellular carcinoma CD8+ T cells Lnc-Tim3 binds to Tim-3 and induces nuclear translocation of Bat3 in hepatocellular carcinoma, which compromises anti-tumor immunity by promoting CD8 + T cell exhaustion. (64)
Lnc-sox5 Colorectal cancer CD8+ T cells Lnc-sox5 regulates the CD8+T cells infiltration and cytotoxicity through modulating the expression of IDO, further affecting the progression of colorectal cancer. (65)
Lnc-EGFR Hepatocellular carcinoma Tregs Lnc-EGFR specially binds to EGFR, enhances AP-1/NF-AT1/Foxp3 signaling, leading to Treg differentiation, and hepatocellular carcinoma progression (68)
LncRNA SNHG1 Breast cancer Tregs Knockdown of lncRNA SNHG1 suppresses Treg differentiation by increasing the expression of miR-448 and reducing level of IDO, further alleviating the immune escape in breast cancer. (69)
Flicr Tregs Flicr modulates the expression of Foxp3 and enhances the immunosuppressive function of Tregs. (70)

CAFs, cancer-associated fibroblasts; TAMs, tumor-associated macrophages; MDSCs, myeloid-derived suppressor cells; Tregs, regulatory T cells.