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. 2019 Aug 6;9:736. doi: 10.3389/fonc.2019.00736

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Copyright © 2019 Li, Lei, Mao, Wang, Xu, Ran, Zhou and He.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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High NAPRT expression is correlated with advanced TNM stage and poor prognosis of CRC patients. (A) The typical images showing the expression of NAPRT in CRC tissue and adjacent tissues. (B) Heat map showing the IHC scores of NAPRT in CRC tissues and corresponding normal intestinal epithelium. (C) IHC scores of NAPRT in CRC tissues with different TNM stages. (D) UALCAN analysis showing the mRNA expression of NAPRT in rectal cancer and normal intestinal epithelium. (E) UALCAN analysis showing the mRNA expression of NAPRT in different stages of rectal cancer. (F) The Kaplan–Meier survival analysis showing DFS of CRC patients with high or low NAPRT expression level. (G) The Kaplan–Meier survival analysis showing OS of CRC patients with high or low NAPRT expression level. (H) The Kaplan–Meier survival analysis showing that OS of CRC patients with high or low NAPRT mRNA expression from GSE24551. (I) The Kaplan–Meier survival analysis showing that OS of CRC patients with high or low NAPRT mRNA expression from GSE30378.COAD, colon adenocarcinoma; READ, rectal adenocarcinoma; *P < 0.05; **P < 0.01; ***P < 0.001.