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. 2019 Aug 6;9:736. doi: 10.3389/fonc.2019.00736

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Copyright © 2019 Li, Lei, Mao, Wang, Xu, Ran, Zhou and He.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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High NAMPT expression is correlated with advanced TNM stage and poor prognosis of CRC patients. (A) The typical images showing the expression of NAMPT in CRC tissue and adjacent tissues. (B) Heat map showing the IHC scores of NAMPT in CRC tissues and corresponding normal intestinal epithelium. (C) IHC scores of NAMPT in CRC tissues with different TNM stages. (D) UALCAN analysis showing the mRNA expression of NAMPT in colon cancer and normal intestinal epithelium. (E) UALCAN analysis showing the mRNA expression of NAPRT in different stages of colon cancer. (F) UALCAN analysis showing the mRNA expression of NAMPT in rectal cancer and normal intestinal epithelium. (G) UALCAN analysis showing the mRNA expression of NAPRT in different stages of rectal cancer. (H) The Kaplan–Meier survival analysis showing DFS of CRC patients with high or low NAPRT expression level. (I) The Kaplan–Meier survival analysis showing OS of CRC patients with high or low NAPRT expression level. COAD, colon adenocarcinoma; READ, rectal adenocarcinoma; *P < 0.05; **P < 0.01; ***P < 0.001.