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. 2019 Aug 8;12:6253–6265. doi: 10.2147/OTT.S209056

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© 2019 Chen et al.

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The inhibitory effects of oxymatrine on α_Ⅴβ₃ integrin/FAK/PI3K/Akt signaling.

Notes: MDA-MB-231 and 4T1 cells were treated with or without oxymatrine (1.5, 3 and 6 μmol/mL) for 48 h. (A) The expression of α_Ⅴ and β₃ integrin was analyzed by Western blot. (B) The expression and co-localization of α_Ⅴ and β integrin were evaluated by immunofluorescence microscopy (magnification, 400×; scale bars, 25 μm). (C) The expression of phosphorylated and total FAK, PI3K, and Akt were detected by Western blot. The values represent the mean ± SEM. *P<0.05 compared with the control group. The statistical data is provided from 3 independent experiments.

Abbreviations: OMT, oxymatrine; FAK, focal adhesion kinase; PI3K, phosphoinositide 3-kinase; Akt, protein kinase B; GAPDH, glyceraldehyde-3-phosphate dehydrogenase.