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. 2019 Sep;370(3):350–359. doi: 10.1124/jpet.119.257204

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Copyright © 2019 by The American Society for Pharmacology and Experimental Therapeutics

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Fig. 2. — Selectivity of VU0071063 for Kir6.2/SUR1 over Kir6.1/SUR2B. Concentration-response curves of the indicated drugs against (A) Kir6.2/SUR1 or (B) Kir6.1/SUR2B expressed in HEK-293 cells determined in thallium flux assays. (C) Concentration-response curves determined in fetal mouse ductus arteriosus vessels. Changes in lumen diameter were measured and are expressed as a percent change in lumen diameter compared with baseline diameter at resting tone. Pinacidil (green, n = 8 vessels) and diazoxide (blue, n = 8 vessels) induced dose-dependent vasodilation, whereas VU0071063 (red, n = 8 vessels) did not. *P < 0.01, pinacidil statistically significantly different from VU0071063. **P < 0.04, diazoxide statistically significantly different from VU0071063.