Table V.
Genotype and allele frequencies of five SNPs of APOBEC3H.
| A, Rs56695217 genotype and allele | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| CHB patients (n=104) | LC patients (n=265) | HCC patients (n=287) | |||||||
| SNP | N (%) | OR (95%Cl) | P-valuea | N (%) | OR (95%Cl) | P-valueb | N (%) | OR (95%Cl) | P-valuec |
| Number detected | n=89 | n=235 | n=241 | ||||||
| CC | 11 (12.4) | 1 | 29 (12.3) | 26 (10.8) | |||||
| CG | 76 (85.4) | 1.03 (0.49,2.17) | 0.94 | 203 (86.4) | 1.26 (0.71,2.25) | 0.43 | 214 (88.8) | 1.17 (0.54,2.56) | 0.69 |
| GG | 2 (2.2) | 0.60 (0.09,4.13) | 0.60 | 3 (1.3) | 0.34 (0.03,3.64) | 0.36 | 1 (0.4) | 0.11 (0.01,1.37) | 0.08 |
| CG+GG | 78 | 1.02 (0.48,2.15) | 0.96 | 206 | 1.25 (0.70,2.22) | 0.45 | 215 | 1.14 (0.53,2.47) | 0.74 |
| C Allele | 98 (55.1) | 1 | 261 (55.5) | 1 | 266 (55.2) | 1 | |||
| G Allele | 80 (44.9) | 0.98 (0.69,1.39) | 0.91 | 209 (44.5) | 0.99 (0.76,1.27) | 0.92 | 216 (44.8) | 1.00 (0.71,1.42) | 0.98 |
| B, Rs139292 genotype and allele | |||||||||
| CHB patients (n=104) | LC patients (n=265) | HCC patients (n=287) | |||||||
| SNP | N (%) | OR (95%Cl) | P-valuea | N (%) | OR (95%Cl) | P-valueb | N (%) | OR (95%Cl) | P-valuec |
| Number detected | n=95 | n=247 | n=250 | ||||||
| DEL | 42 (44.2) | 1 | 111 (44.9) | 1 | 112 (44.8) | 1 | |||
| CAA.DEL | 53 (55.8) | 0.97 (0.60,1.57) | 0.90 | 134 (54.3) | 1.04 (0.72,1.49) | 0.84 | 137 (54.8) | 1.03 (0.91,0.63) | 0.91 |
| CAA | 0 (0.0) | 0.73 (0.66,0.80) | 1.00 | 2 (0.8) | 0.50 (0.60,7.09) | 0.68 | 1 (0.4) | 0.73 (0.66,0.80) | 1.00 |
| DEL+CAA | 53 | 0.99 (0.61,1.60) | 0.95 | 136 | 1.03 (0.72,1.48) | 0.86 | 138 | 1.03 (0.63,1.69) | 0.89 |
| DEL Allele | 137 (72.1) | 1 | 356 (72.1) | 1 | 361 (72.2) | 1 | |||
| CAA Allele | 53 (27.9) | 0.69 (1.00,1.46) | 1.00 | 138 (27.9) | 0.99 (0.75,1.31) | 1.00 | 139 (27.8) | 0.99 (0.69,1.45) | 1.00 |
| C, Rs139297 genotype and allele | |||||||||
| CHB patients (n=104) | LC patients (n=265) | HCC patients (n=287) | |||||||
| SNP | N (%) | OR (95%Cl) | P-valuea | N (%) | OR (95%Cl) | P-valueb | N (%) | OR (95%Cl) | P-valuec |
| Number detected | n=102 | n=263 | n=280 | ||||||
| CC | 41 (40.2) | 1 | 115 (43.7) | 1 | 118 (42.1) | 1 | |||
| CG | 16 (15.7) | 0.84 (0.42,1.68) | 0.63 | 38 (14.4) | 0.95 (056,1.62) | 0.85 | 36 (12.9) | 0.85 (0.42,1.72) | 0.65 |
| GG | 45 (44.1) | 0.87 (0.52,1.44) | 0.58 | 110 (41.8) | 1.78 (0.81,1.70) | 0.39 | 126 (45.0) | 1.07 (0.64,1.79) | 0.79 |
| CG+GG | 61 | 0.86 (0.54,1.38) | 0.53 | 143 | 1.12 (0.79,1.58) | 0.53 | 174 | 1.01 (0.63,1.63) | 0.97 |
| C Allele | 98 (49.4) | 1 | 268 (49.8) | 272 (77.0) | 1 | ||||
| G Allele | 106 (50.6) | 0.89 (0.64,1.23) | 0.48 | 258 (50.2) | 1.15 (0.89,1.48) | 0.28 | 288 (23.0) | 0.98 (0.71,1.35) | 0.90 |
| D, Rs139302 genotype and allele | |||||||||
| CHB patients (n=104) | LC patients (n=265) | HCC patients (n=287) | |||||||
| SNP | N (%) | OR (95%Cl) | P-valuea | N (%) | OR (95%Cl) | P-valueb | N (%) | OR (95%Cl) | P-valuec |
| Number detected | n=89 | n=229 | n=255 | ||||||
| CC | 34 (38.2) | 1 | 86 (37.6) | 1 | 81 (31.8) | 1 | |||
| CG | 20 (22.5) | 1.1 (0.57,2.11) | 0.79 | 56 (24.5) | 1.38 (0.86,2.20) | 0.18 | 74 (29.0) | 1.53 (0.80,2.94) | 0.20 |
| GG | 35 (39.3) | 0.98 (0.55,1.72) | 0.93 | 87 (30.8) | 1.25 (0.82,1.91) | 0.30 | 100 (39.2) | 1.31 (0.73,2.33) | 0.37 |
| CG+GG | 55 | 1.02 (0.61,1.70) | 0.94 | 143 | 1.30 (0.89,1.90) | 0.18 | 174 | 1.39 (0.83,2.24) | 0.21 |
| C Allele | 88 (49.4) | 1 | 228 (49.8) | 1 | 236 (46.3) | 1 | |||
| G Allele | 90 (50.6) | 0.99 (0.70,1.40) | 0.94 | 230 (50.2) | 0.87 (0.68,1.12) | 0.28 | 274 (53.7) | 0.88 (0.63,1.24) | 0.47 |
| E, Rs139316 genotype and allele | |||||||||
| CHB patients (n=104) | LC patients (n=265) | HCC patients (n=287) | |||||||
| SNP | N (%) | OR (95%Cl) | P-valuea | N (%) | OR (95%Cl) | P-valueb | N (%) | OR (95%Cl) | P-valuec |
| Number detected | n=103 | n=263 | n=281 | ||||||
| CC | 17 (16.5) | 1 | 43 (16.3) | 1 | 37 (13.2) | 1 | |||
| CT | 46 (44.7) | 1.02 (0.52,1.97) | 0.96 | 117 (44.5) | 0.26 (0.75,2.10) | 0.39 | 133 (47.3) | 1.36 (0.69,2.69) | 0.38 |
| TT | 40 (38.8) | 1.01 (0.51,2.00) | 0.97 | 103 (39.2) | 1.24 (0.73,2.10) | 0.42 | 111 (39.5) | 1.40 (0.69,2.77) | 0.37 |
| CT+TT | 86 | 1.01 (0.54,1.89) | 0.97 | 220 | 1.25 (0.77,2.03) | 0.37 | 244 | 1.37 (0.72,2.60) | 0.34 |
| C Allele | 80 (38.3) | 1 | 203 (38.6) | 1 | 207 (36.8) | 1 | |||
| T Allele | 126 (61.2) | 1.01 (0.73,1.41) | 0.95 | 323 (61.4) | 0.93 (0.73,1.86) | 0.55 | 355 (63.2) | 1.09 (0.78,1.51) | 0.61 |
The two-sided χ2 test or Fisher's exact test was used in the comparison of allele distributions.
a
CHB vs. LC
b
LC vs. HCC
c
CHB vs. HCC, adjusted for age, gender, smoking and alcohol consumption by logistic regression analysis. APOBEC3, apolipoprotein B mRNA-editing catalytic polypeptide-like 3; SNPs, single nucleotide polymorphisms; CHB, chronic hepatitis B; LC, liver cirrhosis; HCC, hepatocellular carcinoma; OR, odds ratio; CI, confidence intervals.