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Effects of AGEs on MIF mRNA and protein expression. PC12 cells were treated with different concentrations of AGEs, and the relative expression of MIF (A) mRNA and (B) protein was determined. (C) Quantification of protein expression. The results indicated that AGEs induced MIF expression. Data are presented as the mean ± SD; n=3. *P<0.05, **P<0.01. AGEs, advanced glycation end products; MIF, macrophage migration inhibitory factor.
