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Schematic presentation of the signaling pathways in human gastric cancer cells affected by BQ and OQ. A proposed mechanism of BQ and OQ anticancer activity as related to the MAPK, AKT and STAT3 signaling pathways. BQ, 2-(butane-1-sulfinyl)-1,4-naphthoquinone; OQ, 2-(octane-1-sulfinyl)-1,4-naphthoquinone; Cas 3, caspase-3; ROS, reactive oxygen species.
