Figure 1.

Effect of hypoxia on miR-98 expression in vivo and in vitro. (A) Morphology of the lung PA from normoxia and hypoxic rats was examined with hematoxylin and eosin staining (magnification, ×200). (B) Measurement of RVSP. ***P<0.001 (n=10). (C) The expression of miR-98 in lung pulmonary arteries of HPH rats was examined by RT-qPCR. **P<0.01 (n=10). (D) The miR-98 expression in rat primary PASMCs stimulated with different concentrations of O₂ at 24 and 48 h were examined by RT-qPCR. *P<0.05 and **P<0.01. (n=3). miR, microRNA; PA, pulmonary artery; RVSP, right ventricular systolic pressure; HPH, hypoxic pulmonary hypertension; RT-qPCR; reverse transcription quantitative polymerase chain reaction; NS, not significant.