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Downregulation of Hrd1 expression increases Nrf2 expression in UV-irradiated human dermal fibroblasts. (A) Human fibroblasts were transfected with si-Hrd1-1 and si-Hrd1-2 for 48 h, and then, the protein level of Hrd1 was assessed. (B) Human fibroblasts were transfected with si-Hrd1-1 and si-Hrd1-2 for 24 h, and then, exposed to UVA and UVB. The protein level of Nrf2 was assessed. Hrd1, 3-hydroxy-3-methylglutaryl reductase degradation; Nrf2, NF-E2-related factor 2; UV, ultraviolet.
