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. 2019 Jul 8;20(3):2091–2100. doi: 10.3892/mmr.2019.10474

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Copyright: © Lu et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 6. — DP inhibits the JAK2/STAT3 and AKT/FOXO3a signaling pathways in ECA109 cells. ECA109 cells were treated DP (0, 40, 60 and 80 µM) for 24 h. (A and B) Phosphorylation and expression of JAK2 and STAT3 were determined using western blot analysis. (C and D) Phosphorylation and expression of AKT and FOXO3a were determined using western blot analysis. (E) The ratio of phosphorylated protein/total protein (p-JAK2/JAK2, p-STAT3/STAT3, p-AKT/AKT, p-FOXO3a/FOXO3a). The data are expressed as the mean ± standard deviation (n=3). *P<0.05 compared with the control group. DP, dracorhodin perchlorate; JAK2, Janus kinase 2; STAT3, signal transducer and activator of transcription 3; FOXO3a, forkhead box O3a.