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. 2019 Jul 1;20(3):2227–2235. doi: 10.3892/mmr.2019.10449

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Copyright: © Tian et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 4. — Siah-1 mediates the nuclear accumulation of GAPDH. (A) Expression of siah-1 was significantly decreased by siah-1 siRNA. (B) Nuclear interaction between GAPDH/siah-1 following Hcy treatment was inhibited in C6 cells following siah-1 silencing. (C) Nuclear translocation of siah-1 and GAPDH following Hcy treatment in C6 cells with siah-1 silencing. Images were acquired with a Zeiss LSM710 confocal microscope (magnification, ×100). *P<0.05 vs. NC group. Hcy, homocysteine; GAPDH, glyceraldehyde 3-phosphate dehydrogenase; siRNA, small interfering RNA; NC, negative control.