Figure 1.

Analysis plan. The key genes were determined by integrating the methylation and mRNA expression profile microarray datasets and then confirmed using TCGA and HPA data. DAVID, Database for Annotation, Visualization and Integrated Discovery; DEGs, differentially expressed genes; DMGs, differentially methylated genes; GEO, Gene Expression Omnibus; GO, Gene Ontology; HPA, Human Protein Atlas; KEGG, Kyoto Encyclopedia of Genes and Genomes; limma, Linear Models for Microarray Data; PPI, protein-protein interaction; TCGA, The Cancer Genome Atlas.