Table II.
KEGG pathway enrichment for methylation-related differentially expressed genes.
| A, Downregulated/hypermethylated genes | |||
|---|---|---|---|
| KEGG ID | KEGG pathway | P-value | Genes |
| hsa04610 | Complement and coagulation cascades | 3.13×10−3 | C8B, C7, KLKB1, C1R |
| hsa00250 | Alanine, aspartate and glutamate metabolism | 3.81×10−3 | ASPA, GOT1, ASS1 |
| hsa00380 | Tryptophan metabolism | 6.04×10−3 | AADAT, IDO2, KMO |
| hsa00460 | Cyanoamino acid metabolism | 6.82×10−3 | GBA3, GGT5 |
| hsa00830 | Retinol metabolism | 1.02×10−2 | CYP4A11, CYP26A1, RDH16 |
| hsa04060 | Cytokine-cytokine receptor interaction | 2.67×10−2 | CCL2, IL1RAP, NGFR, CXCL12, GHR |
| hsa00270 | Cysteine and methionine metabolism | 2.91×10−2 | GOT1, BHMT |
| hsa00620 | Pyruvate metabolism | 3.33×10−2 | LDHD, ACOT12 |
| hsa00071 | Fatty acid metabolism | 3.33×10−2 | CYP4A11, ACADS |
| hsa00983 | Drug metabolism | 3.53×10−2 | NAT2, UPP2 |
| hsa04115 | p53 signaling pathway | 4.98×10−2 | GADD45B, IGFBP3 |
| B, Upregulated/hypomethylated genes | |||
| hsa03030 | DNA replication | 1.70×10−5 | RFC4, RNASEH2A, MCM4, FEN1, MCM6 |
| hsa04110 | Cell cycle | 1.79×10−2 | RAD21, SFN, MCM4, MCM6 |
| hsa04120 | Ubiquitin mediated proteolysis | 4.67×10−2 | UBE2C, UBE2Q1 |
| hsa05200 | Pathways in cancer | 4.79×10−2 | LAMC1, CTNNA1 |
KEGG, Kyoto Encyclopedia of Genes and Genomes.