Fig. 4.

High motif-x scores are not indicative of high statistical significance. Panels A and B show the number of empirically significant motifs reported by motif-x* and a scatter plot of motif significance versus the reported motif-x score, respectively, when motif-x* uses shuffled foreground peptides as the background peptides. Panels C and D give the same information when motif-x* extracts the background peptides from the P. falciparum proteome. In both cases, the foreground peptides (input dataset) are from the Pease et al. (2018) Supplementary Data S2 file. Empirical P-values are estimated from 10 000 runs of motif-x* on shuffled versions of the input dataset