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. 2019 Aug 6;10:857. doi: 10.3389/fphar.2019.00857

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Copyright © 2019 Guo, Cai, Wu, Fan, Huang, Zhou, Wu, Huang, Zhao, Zhang, Wang, Zhang and Fang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Circos plot visualizes the predicted cancer indications of berberine. The red connected lines represent the calculated −Log₁₀ (q) value of each berberine-cancer type pair based on Fisher’s exact test, while the blue ones represent the corresponding number of overlapped targets. The predicted cancer indications with literature validation were highlighted in bold font. We classified the 18 predicted cancer indications into four neoplasm categories according to Medical Subject Headings (MeSH) system (https://www.ncbi.nlm.nih.gov/mesh/68009371).