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. 2019 Aug 6;13:169. doi: 10.3389/fnbeh.2019.00169

Figure 5.

Figure 5

The effect of S-Equol (SE) dose (Placebo, 0.05 mg, 0.1 mg, 0.2 mg) on the number of misses, which reflect a lapse of attention to the stimulus, was examined. (A) Treatment with SE did not significantly alter the number of misses across signal duration (i.e., 1,000, 500, 100 ms) in control animals. (B) For clarity, only the placebo and 0.2 mg SE dose groups are presented. A downward shift in the number of misses was observed as SE dose increased, with the most prominent shift observed in HIV-1 Tg animals treated with 0.2 mg SE. (C) HIV-1 Tg animals displayed a linear decrease in the number of misses at the 100 ms signal duration as the dose of SE increased. A horizontal line, however, provided a well-described fit for the control animals, supporting no change in the number of misses at 100 ms as a function of SE treatment. The number of misses in HIV-1 Tg animals treated with 0.2 mg SE approached the level of controls.