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. 2019 Aug 6;13:169. doi: 10.3389/fnbeh.2019.00169

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Copyright © 2019 Moran, McLaurin, Booze and Mactutus.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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A pretest-posttest experimental design was utilized to examine the effect of S-Equol [SE; Placebo (A,C) or 0.2 mg (B,D)] on the number of misses across time in control (A,B) and HIV-1 Tg (C,D) animals. Neither placebo nor 0.2 mg SE treatment altered the number of misses in control animals across time (A,B), evidenced by a global first-order polynomial fit. HIV-1 Tg animals treated with placebo displayed an increase in the number of misses at the post-SE assessment relative to the pre-SE assessment (C), supporting neurocognitive decline across time; an effect that was prevented by treatment with 0.2 mg SE (D).