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. 2019 Aug 6;9:707. doi: 10.3389/fonc.2019.00707

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Copyright © 2019 Pernas, Petit, Climent, Paré, Perez-Martin, Ventura, Bergamino, Galván, Falo, Morilla, Fernandez-Ortega, Stradella, Rey, Garcia-Tejedor, Gil-Gil and Prat.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effect of PAM50 signatures (as continuous variables) on pathological complete response (pCR) in the univariate analysis (A) and after adjusting for hormone receptor variables (B). Each signature has been standardized to have a mean of 0 and a standard deviation of 1. The size of the square is inversely proportional to the standard error. Horizontal bars represent the 95% CIs of ORs. Statistically significant variables are shown in blue. Each gene signature has been evaluated individually and ranked ordered based on the estimated OR. ROR-S, risk of recurrence score based on subtype; ROR-P risk of recurrence score based on subtype and proliferation.