Table I.
Key pharmacokinetic parameters for plasma, subcutaneous adipose tissue, and cancellous bone
| Pharmacokinetic parameter | Plasma | Subcutaneous adipose tissue | Cancellous bone | Overall comparison* |
|---|---|---|---|---|
| Mean AUC0 – last, min μg/ml (95% CI) | 3347 (2689 to 4005) | 4944 (4286 to 5602)† | 1874 (1216 to 2532)† | p < 0.001 |
| Mean Cmax, μg/ml (95% CI) | 74.3 (60.0 to 88.7) | 81.6 (67.2 to 96.0) | 21.4 (7.0 to 35.8)‡ | p < 0.001 |
| Mean Tmax, mins (sd) | 13.3 (8.2) | 22.5 (0.0) | 37.5 (0.0) | N/A |
| Mean T½, mins (95% CI) | 38.2 (32.8 to 43.5) | 43.5 (38.2 to 48.9) | 51.4 (46.0 to 56.7)§ | p < 0.002 |
| Mean AUCtissue/AUCplasma (95% CI) | N/A | 1.50 (1.14 to 1.87) | 0.56 (0.49 to 0.64) | N/A |
*
Overall comparison using F test for plasma, subcutaneous adipose tissue, and cancellous bone
†
p < 0.005 for comparison with the corresponding plasma value
‡
p < 0.001 for comparison with both plasma and subcutaneous adipose tissue
§
p < 0.05 for comparison with both plasma and subcutaneous adipose tissue
AUC0–last, area under the concentration–time curve from 0 to the last measured value; CI, confidence interval; Cmax, peak drug concentration; Tmax, time to Cmax; N/A, not applicable; T1/2, half-life at β-phase; AUCtissue/AUCplasma, tissue penetration expressed as the ratio of AUCtissue/AUCplasma