Table III.
Healthy porcine cancellous bone pharmacokinetic parameters of different antimicrobials obtained by microdialysis
| Pharmacokinetic parameter | Meropenem | Cefuroxime7 | Vancomycin2 |
|---|---|---|---|
| Mean AUCtissue/AUCplasma (95% CI) | 0.56 (0.49 to 0.64) | 0.79 (0.67 to 0.91) | 0.59 (0.42 to 0.75) |
| Cmax, μg/ml (95% CI) | Mean: 21.4 (7.0 to 35.8) | Mean: 22.9 (16.3 to 29.5) | Median: 15.7 (10.9 to 20.4) |
| Tmax, mins | Mean: 37.5 (sd 0) | Median: 45 (range: 15 to 45) | Median: 191 (95% CI: 149 to 233) |
| T½, mins (95% CI) | Mean: 51.4 (46.0 to 56.7) | Median: 36.7 (32.0 to 41.3) | Median: 255 (206 to 305) |
AUCtissue/AUCplasma, tissue penetration expressed as the ratio of AUCtissue/AUCplasma; CI, confidence interval; Cmax, peak drug concentration; Tmax, time to Cmax; T1/2, half-life at β-phase