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. 2019 Jul 9;9(17):5105–5121. doi: 10.7150/thno.33904

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This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/). See http://ivyspring.com/terms for full terms and conditions.

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Overview of experimental design. (A) MACS enrichment of CD146⁺ ADSCs. (B) Comparison of cytological characteristics between ADSCs and CD146⁺ ADSCs in vitro. CD146⁺ ADSCs retained good viability, proliferation ability, and stem cell character after sorting. CD146⁺ ADSCs also showed pericyte characteristics, better immune properties, and inflammation regulation ability. (C) A schematic illustration of the intra-articular injection of CD146⁺ ADSCs in rats. (D) Flow chart of the preparation of the cell-scaffold composite for long term cartilage repair in rabbits.