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. 2019 Jul 9;9(17):5105–5121. doi: 10.7150/thno.33904

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Radiography assessment of the cartilage in rabbits with cell-scaffold composites treatment. (A) Experimental design for the cartilage repair. The rabbits were randomly allocated into five groups: defects without treatment (negative control), defects treated with ACECM scaffold, defects treated with ACECMs and ADSCs, defects treated with ACECMs and CD146⁺ cells, and native group. (B) X-ray images of rabbit knees 3 and 6 months after surgery. (C) MRI of rabbit knees 3 months and 6 months after surgery. Red arrow indicates the defected area. The inset in the bottom left corner of each T2 mapping image shows the cartilage labeled by pseudo-color. (D) MRI scoring system for evaluation of cartilage repair after 3 and 6 months. Data are expressed as mean ± SD, *P < 0.05, **P < 0.01, ***P < 0.0001.