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. 2019 Jul 9;9(17):5105–5121. doi: 10.7150/thno.33904

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Macroscopic and histological evaluation of cartilage repair after cell-scaffold composite treatment. (A) Macroscopic observations of rabbit knees (distal femur and tibial plateau) 3 and 6 months after surgery. (B) (C) ICRS scoring system for macroscopic evaluation of cartilage repair after 3 months (B) and 6 months (C). Data are expressed as mean ± SD, *P < 0.05, **P < 0.01, ***P < 0.0001. (D) Histological analysis of the cartilage defect after 3 and 6 months by H&E and Sirius Red staining. Black solid arrows denote the repair interface. Red solid arrows denote the depth of the repaired cartilage. HC, host cartilage; RC, repaired cartilage. Scale bar: 200 μm. (E) (F) ICRS scoring system for histological evaluation of cartilage repair after 3 months (E) and 6 months (F).