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. 2019 Jul 9;9(17):5065–5084. doi: 10.7150/thno.34014

Figure 1.

Figure 1

Cdc42 knockout mice show rapid postnatal lethality and abnormal inside-out and outside-in barrier function. (A) Cdc42 KO and WT control mice at E14.5, E15.5, E16.5, E17.5, E18.5, and P1. (B) The mean weight (g) of Cdc42 KO mice compared with that of WT littermates at E17.5, E18.5 and P1 (n = 8). (C) Comparison of the gross morphology of the skin in control and Cdc42 KO mice. (D) TEWL measurement at P1 (n = 8), *p<0.05. (E) The weight/birth weight ratios of Cdc42 KO and WT littermates at different time points (n = 8). (F) Skin permeability assay using X-gal staining in control and Cdc42 KO mice. (G) SEM of dorsal skin of E17.5 and P1 mice (the arrow shows a gap between epidermal corneocytes; n = 8). Scale bars: 5 μm.