Table 5. Change in the Melting Temperatures (ΔTm), Affinities (Kd), and Efficiency Metrics of Compounds 26g, 26j–o, and 27g.
a
100 μM ligand and 10 μM Mab TrmD.
b
kcal mol–1 per heavy atom.
c
Not determined due to solubility.
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