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. 2019 Jul 8;62(15):7210–7232. doi: 10.1021/acs.jmedchem.9b00809

Table 7. Minimum Inhibitory Concentrations (MIC) against Mab and Mtb of Compounds 26l, 28, 29a–e, and 31a–b.

			H37Rv Mtb MIC (μM)
compound	Mab TrmD K_d (μM)	Mab MIC (μM)	GAST-Fe	7H9/ADC	7H9/glucose	7H9/DPPC
26l	0.12 ± 0.02	50	50	>100	ND	ND
28	0.092 ± 0.018	50	ND	ND	ND	ND
29a^a	0.027 ± 0.004	50	50	>100	25	12.5
29b	0.070 ± 0.029	50	50	100	25	12.5
29c	0.19 ± 0.02	50	50	>100	100	50
29d^a	0.073 ± 0.030	50	25	50	12.5	6.3
29e	0.10 ± 0.02	50	6.3	12.5	2.3	1.6
31a^a	0.49 ± 0.21	50	25	100	12.5	6.3
31b	0.71 ± 0.09	50	50	>100	25	12.5

^a

Mab MIC and H37Rv Mtb MIC (7H9/DPPC) previously reported.¹²